Progesterone (English: Progesterone, also known as progesterone, progesterone, progesterone, progesterone, progesterone, progesterone, progesterone, progesterone, progesterone or progesterone, abbreviated to P4, also known as (progesterone 4-ene-3, 20-dione), is an endogenous steroid and progesterone sex hormone, and is also the main progesterone in the body, secreted by the ovaries of women. Progesterone is a steroid hormone secreted by the luteal cells of the ovary, which contains 21 carbon progesterone Chemicalbook. It is also the intermediate product of all steroid hormones and belongs to one of the progesterone. There are two types of crystals, α- type and β- type, both of which have the same physiological activity of Chemicalbook. α- type is precipitated from dilute ethanol and is an orbicular white prismatic crystal, while β- type is an orbicular white acicular crystal. Both are insoluble in water but soluble in ethanol, ether, chloroform, acetone, dioxane and concentrated sulfuric acid.
White powdery solid
It has significant morphological effect on the endometrium stimulated by estrogen in vivo, which is necessary for the maintenance of pregnancy. In the late period of menstruation and estrogen together to promote endometrial growth and hyperplasia, so that the proliferation period into the secretion period, for fertilized egg implantation and embryo development to create conditions; During menstruation, the endometrium is completely shed; Inhibit the movement of the uterus and the sensitivity to oxytocin during pregnancy, have antifetal effect, and together with estrogen to promote mammary gland into the Chemicalbook step development, ready for milk; A large dose can suppress luteinizing hormone secreted by the anterior pituitary gland through the feedback regulation of hypothalamic-anterior pituitary lobular-ovarian axis, thus inhibiting ovulation and playing a contraceptive role. Used for habitual abortion, threatened abortion, functional uterine bleeding, blood insipidus, dysmenorrhea, endometriosis, amenorrhea, ureteral stones. Prostatic hyperplasia, sleep apnea syndrome and refractory cirrhosis ascites.
Melting point: 128-132 ° C (lit.)
Specific rotation :186º(C =1,ethanol)
Boiling point: 394.13 ° C (roughestimate)
Density: d231.166; d201.171
Refractive index: 182 ° (C = 2, Dioxane)
Flash: Chemicalbook2 ℃
Storage condition: RoomTemp
Solubility: H2O: 25 mg/mL, maybecleartoslightlyhazy
Water solubility: < 0.1 g / 100 mlat19 DHS C